Positions
- Associate Professor, Chemistry, College of Arts and Sciences
- Contact Info
Co-author Network
Map of Science
Co-investigator Network
Adam Richard Offenbacher
Affiliation
Publications
selected publications
presentations
-
presentation
- Using Course-based Undergraduate Research to Expand Student Understanding of Quantum Phenomena in Biological Chemistry, National Association for Research in Science Teaching 2025
- Chorographic Mapping of Human Fibrinogen Structures in Solution, 27th International Fibrinogen Workshop 2024
-
Structural Dynamism of Human Fibrinogen
, 11th Symposium on Hemostasis 2024 -
Identifying Productive Protein Thermal Motions Associated with Hydrogen Tunneling in the Lipoxygenase Reaction
, Quantum Biology Seminar Series; UCLA 2023 - Biochemical and structural studies of unusual lipoxygenases from pathogenic fungi, American Chemical Society Southeast Regional Meeting 2023
- Hydrogen tunneling in biochemistry lab: Introducing undergraduate students to quantumbiology research in the classroom, American Chemical Society Southeast Regional Meeting 2023
- To Tunneling and Beyond: Investigations into the Oxidation of Fatty Acids by Lipoxygenases, Texas Tech 2023
- Identification of protein networks for dynamic activation of hydrogen tunneling inlipoxygenases., American Chemical Society Southeast Regional Meeting 2023
- Studying hydrogen quantum tunneling across a plant lipoxygenase library in a biochemistrycourse-based undergraduate research experience (CURE) Laboratory, American Chemical Society Southeast Regional Meeting 2023
- Resolving the allosteric regulation of human 15-lipoxygenase-2, American Chemical Society National Meeting & Expo 2022
- Fibrinogen Farming: Exploring Transient Recombinant Expression and Affinity-Based Purification of Human Fibrinogen, 2022 Hemostasis Gordon Research Conference 2022
- Towards a Robust Recombinant Expression and Purification Process for Human Fibrinogen, 26th International Fibrinogen Research Society Worskshop 2022
- Mechanisms and thermal activation barriers of lipoxygenase catalyzed C-H cleavage by tunneling, XXth International Workshop on Quantum Atomic and Molecular Tunneling Systems 2022
- Assessing and Developing Protocols for Purifying Fibrinogen From Human Blood Plasma, East Carolina University Research and Creative Achievement Week 2022
- Fabricating Rapid Transient Recombinant Expression and Affinity Chromatography Systems for Human Fibrinogen, East Carolina University Research and Creative Achievement Week 2022
- To Tunneling and Beyond: Investigations into the Oxidation of Fatty Acids by Lipoxygenases, Case Western Reserve University 2022
- Dynamic allostery networks in plant and animal 15-lipoxygenases, American Chemical Society National Meeting & Expo 2022
- Investigation into the thermal activation of 15-lipoxygenase-2, American Chemical Society National Meeting & Expo 2022
- Resolving and Linking the Role of Conformational Flexibility to the Allosteric Regulation of Human Lipoxygenases Implicated in Inflammation, 30th Suddath Symposium in memory of Bridgette Barry 2022
- Thermal Activation Barriers of Enzyme Catalyzed C-H Cleavage by Tunneling in Lipoxygenases, International Converence on Catalysis and Engineering 2022
- Novel Affinity-based Fibrinogen Purification Strategies, 2021 Annual BMES Meeting 2021
- Effects of N-linked Glycans on Fibrinogen Turbidity Assay, East Carolina University Research and Creative Achievement Week 2021
- Measuring the Effects of Fibrinogen Glycosylations on Fibrin Polymerization using Turbidity, SoDM Celebration of Research and Scholarship (CORAS) 2020 2021
- Allosteric Regulation of Human Epithelial 15-Lipoxygenase-2, SouthEastern Regional Meeting of the American Chemical Society (SERMACS) 2021
- Thermodynamic, dynamic light scattering, and hydrogen deuterium exchange investigation of fatty acid regulation of soybean lipoxygenase reveals dynamically driven allostery, SouthEastern Regional Meeting of the American Chemical Society (SERMACS) 2021
- Proton and electron tunneling effects in enzymes, American Physics Society March Meeting 2020
- Role of Tryptophan and its Derivatives in Elucidating a PCET Mechanism in Azurin, 2020 Research and Creative Activity Week 2020
- Direct Electrochemical Detection of Electrostatic Effects on the Redox Properties of Tryptophan Sidechains in Azurin, ACS Spring 2020 National Meeting 2020
- Chemoenzymatic Synthesis of an Unnatural Tryptophan with a Unique Pourbaix Diagram, American Chemical Society Southeast Regional Meeting 2019
- Kinetic characterization of the C-H activation step for the lipoxygenase from the pathogenic fungus Magnaporthe oryzae: Impact of N-linked glycosylation, SouthEastern Regional Meeting of the American Chemical Society (SERMACS) 2019
- Resolving the Origins of Thermal Activation of Enzymatic C-H Bond Cleavage, SouthEastern Regional Meeting of the American Chemical Society (SERMACS), Invited Speaker 2019
- Temperature Dependent Kinetic Isotope Effects Reveal the Origins of Efficient Enzymatic C-H Activation, Invited Speaker, Isotopes 2019 - The Cross-Disciplinary Conference on Stable Isotope Sciences 2019
- Detection of dynamical protein networks for thermal activation and protein allostery, Enzyme Mechanisms Conference 2019
- A protein network modulates enzyme-substrate conformations linked to catalytic efficiency in lipoxygenase C-H activation, 31st Chinese Chemistry Society (CCS) Congress 2018
- Kinetic Characterization of the C-H Activation Step for the Lipoxygenase from the Pathogenic Fungus Magnaporthe oryzae: Impact of N-linked Glycosylation, ACS Spring 2020 National Meeting
- Thermodynamic studies of tryptophan oxidation in azurin: Implications for water in mediating biological proton-coupled electron transfer, Georgia Tech Spring Symposium Department of Chemistry
Research
principal investigator on
- Collaborative Research: Mapping and comparing the link of the protein scaffold to quantum events in thermally activated enzymes and flavin-based photoreceptors awarded by NSF - National Science Foundation 2023 - 2026
- Study of Quantum Tunneling Mechanism Towards the Development of Enhanced Proton Tunneling in Enzymatic-based Biocatalysts awarded by Toyota Motor Engineering & Manufacturing, North America, INC 2024 - 2025
- Conformational flexibility of lipoxygenases and its role in regulation and substrate acquisition awarded by Louisiana State University (LSU) 2021 - 2024
- Identifying structural differences between fibrinogen and fibrin to provide novel therapeutic targets awarded by National Institutes of Health 2019 - 2023
- RUI: Development of Unnatural Tryptophan Derivatives to Expand Tryptophan Function and to Study Biological Catalysis awarded by National Science Foundation (NSF) 2020 - 2023
- Development of novel tryptophan analogues to study and expand protein function awarded by ECU URCA (STEM) 2018
- Identifying Key Residues in 15-LOX-2 Enzyme for Interactions with Allosteric Effectors awarded by ECU URCA (STEM) 2018
- Elucidation of 15-Lipoxygenase-2 and PEBP1 Interactions Implicated in Acute Renal Failure awarded by ECU URCA (STEM) 2018
Background
education and training
- B.S. in Biochemistry, Ohio Northern University
- Ph.D. in Chemistry, Georgia Institute of Technology