Positions

Associate Professor, Kinesiology, College of Health and Human Performance

Contact Info

huangh@ecu.edu

Publications in VIVO

Co-author Network

Co-investigator Network

Hu Huang

member of

European Collage Sports Science 2006 - 2025
Frontiers in Cellular Neurophysiology 2021
Frontiers in Exercise Physiology 2021
Frontiers in neuroendocrine Science 2021
The Obesity Society 2015 - 2019
The Society of Neuroscience 2015 - 2019
America Diabetes Association 2014 - 2019
American Collage of Sports Medicine 2014 - 2019
American Heart Association 2012

selected publications

article
- Selective Deletion of FGFR1 in AgRP Neurons Impairs Energy Homeostasis Under High-Fat Diet in Mice
  . Molecular Metabolism. 2026
- Deletion of FGFR1 in hypothalamic neurons alters energy homeostasis and negates the metabolic effects of -Klotho. Endocrinology. 167. 2025
- The effects of Ghrelin on hypothalamic Agouti-Related Protein expressing in GT1-7 cell lines. Journal of Captital Medical University. 43:924-930. 2022
- Exercise increases NPY/AgRP and TH neuron activity in the hypothalamus of female mice. The Journal of endocrinology. 252:167-177. 2022
- Intrinsic adaptations in OXPHOS power output and reduced tumorigenicity characterize doxorubicin resistant ovarian cancer cells. Biochimica et biophysica acta. Bioenergetics. 1863. 2022
- Centrally circulating -klotho inversely correlates with human obesity and modulates arcuate cell populations in mice. Molecular Metabolism. 44. 2021
- Circulating -klotho regulates metabolism via distinct central and peripheral mechanisms. Metabolism: clinical and experimental. 121. 2021
- Energy Status Differentially Modifies Feeding Behavior and POMC Neuron Activity After Acute Treadmill Exercise in Untrained Mice. Frontiers in endocrinology. 12. 2021
- Mini review: The relationship between energy status and adult hippocampal neurogenesis. Neuroscience Letters. 765. 2021
- Tissue-Specific Approaches Reveal Diverse Metabolic Functions of Rho-Kinase 1. Frontiers in endocrinology. 11. 2021
- ARC Neuron Activity Is Required for Acute Exercise-Induced Food Intake in Un-Trained Mice. Frontiers in Physiology. 11. 2020
- ApolipoproteinJ is a hepatokine regulating muscle glucose metabolism and insulin sensitivity. Nature Communications. 11. 2020
- Central -Klotho Suppresses NPY/AgRP Neuron Activity and Regulates Metabolism in Mice. Diabetes. 69:1368-1381. 2020
- -Klotho expression in mouse tissues following acute exhaustive exercise.. Frontiers in Physiology. 2019
- Administration of alpha klotho reduces liver and adipose lipid accumulation in obese mice.. Heliyon. 2019
- Phospholipid methylation regulates muscle metabolic rate through Ca2+ transport efficiency. Nature Metabolism. 876-885. 2019
- Vertical sleeve gastrectomy improves liver and hypothalamic functions in obese mice. The Journal of endocrinology. 2019
- Effects of sleeve gastrectomy in mice by using titanium clip.. International Journal of Surgery. 2018
- Modulation of excitatory glutamate receptivity in hypothalamic AgRP/NPY neuron by fasting.. Frontier Cellular Neuroscience. 2018
- Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition.. Journal of Clinical Investigation. 2018
- The effects of exercise on hypothalamic neurodegeneration of Alzheimer's disease mouse model. PLOS ONE. 2018
- Antisense oligonucleotide and thyroid hormone conjugates for obesity treatment. Scientific Reports. 7. 2017
- Exercise improves hypothalamic function induced by high-fat diet. Immunoendocrinology. 2016
- Insulin in the nervous system and the mind: functions in metabolism, memory, and mood. Molecular Metabolism. 2016
- Voluntary exercise improves hypothalamic and metabolic function in obese mice. Journal of Endocrinology. 2016
- Clusterin/ApoJ enhances central leptin signaling through Lrp2-mediated endocytosis. EMBO Reports. 15:801-808. 2015
- Bilirubin Increases Insulin Sensitivity in Leptin-Receptor Deficient and Diet-Induced Obese Mice Through Suppression of ER Stress and Chronic Inflammation. Endocrinology. 155:818-828. 2014
- ROCK1 isoform-specific deletion reveals a role for diet-induced insulin. American Journal of Physiology-Endocrinology and Metabolism. 306. 2014
- Regulation of Hepatic Energy Metabolism and Gluconeogenesis by BAD. Cell Metabolism. 19:272-284. 2014
- Clusterin and LRP2 are critical components of the hypothalamic feeding regulatory pathway. Nature Communications. 4. 2013
- Metabolic actions of Rho-kinase in periphery and brain.. Trends in Endocrinology and Metabolism. 24:506-514. 2013
- ROCK1 in AgRP Neurons Regulates Energy Expenditure and Locomotor Activity in Male Mice. Endocrinology. 154:3660-3670. 2013
- Regulation of glucose transport by ROCK1 differs from that of ROCK2 and is controlled by actin polymerization. Endocrinology. 153:1649-1662. 2012
- Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling.. Nature Neuroscience. 15:1391-1398. 2012
- Selective PPARÎ modulator INT131 normalizes insulin signaling defects and improves bone mass in diet-induced obese mice. American Journal of Physiology-Endocrinology and Metabolism. 302. 2012
- Influence of adiponectin gene polymorphism SNP276 (G/T) on adiponectin in response to exercise training. Endocrine Journal. 54:879-886. 2007
- The regulation of adiponectin receptors expression by acute exercise in mice. Experimental and Clinical Endocrinology and Diabetes. 115:417-422. 2007
- The effect of exercise training on adiponectin receptor expression in KKAy obese/diabetic mice. Journal of Endocrinology. 189:643-653. 2006

presentations

presentation

principal investigator on

FGFR1 Signaling in AgRP Neurons for Regulating Metabolism awarded by DHHS - National Institutes of Health (NIH) 2024 - 2028
The central role of a-klotho in regulation of metabolism resubmission awarded by DHHS - NIH/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDKD) 2019 - 2024
The role of medial basal glutamatergic neurons to control metabolism during exercise and recovery. awarded by American College of Sports Medicine Foundation (ACSM) 2017 - 2018
East Carolina University Research Start-up Award 2014
East Carolina University Research Start-up Award 2013

investigator on

Rodent Metabolic Phenotyping System awarded by DHHS - National Institutes of Health (NIH) 2023 - 2024

professional service activities

Journal of Human Endocrinology 2015 - 2022
Obesity Serving as a reviewer 2021
Journal of Diabetes & Metabolic Syndrome Disorders 2015 - 2021
Frontiers in Cellular Neuroscience Review Editor inCellular Neurophysiologyfor Frontiers in Cellular Neuroscience 2020
Frontiers in Endocrinology Guest Associate Editor inNeuroendocrine Sciencefor frontiers in Endocrinology 2019
FEBS Journal Review and evaluate scientific manuscript submitted to FEBS Journal. 2017 - 2019
Heliyon 2016 - 2019
Journal of Applied Physiology Journal of Applied Physiology reviewer 2017 - 2018
Medicine & Science in Sports & Exercise 2016 - 2017
Heliyon, Elsevier's new open access journal covering all scientific disciplines. 2014 - 2015
Metabolism 2013

located in facility

115 Heart Dr, Room 4107