overview

• Dr. Nicholas Broskey is a translational scientist focusing on skeletal muscle physiology. Particularly, Dr. Broskey is interested in the role of mitochondria in health and disease and how exercise interventions can help ameliorate conditions of metabolic disease through mitochondrial biology. Dr. Broskey has worked on interventions involving exercise training in elderly individuals at risk for diabetes and now focuses on the opposite side of the age spectrum in infants. He is interested in how maternal health during pregnancy programs infants in utero for future metabolic health outcomes. Dr. Broskey is trained in phenotyping both adults and infants and has clinical expertise in prescribing exercise interventions as well as measuring glycemic control and energy expenditure in humans, including the hyperinsulinemic-euglycemic clamp and indirect calorimetry (respiratory chamber, ventilated hood). He also has basic lab experience in measuring skeletal muscle mitochondrial content and function as well as cell biology techniques using mesenchymal stem cell models, a unique model that when differentiated into a myogenic or adipogenic phenotype represents fetal tissue. Using these stem cell models, his future research plans involve delving further into developmental programming of obesity and diabetes. The data generated will particularly focus on mitochondria as potential cellular organelles responsible for imprinting of metabolic health status in infants.