Metabolic inflexibility is related to elevated muscle anaerobic glycolysis
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Overview
abstract
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The significance of these studies is the demonstration that compromised substrate oxidation in skeletal muscle occurs not only in the obese with the metabolic syndrome but can also be found in non-obese, apparently healthy individuals. Further this metabolic defect can be reversed by bariatric surgery. Our proposed studies focus on further identification of this mechanism and the potential of identifying vulnerable persons for early prevention
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