Molecular Transducers of the Health Benefits of Exercise Intensity and Mode.

): The objective of this study is to collaborate with investigators at Duke (William Kraus) and Wake Forest (Barbara Nicklas) to form a clinical site which will participate in the Molecular Transducers of Physical Activity (MoTrPAC) initiative of the NIH (RFA-RM-15-015). The objective of the project is to exercise training previously sedentary individuals and obtain muscle, fat, and blood to provide to analytical centers of the project for analyses. Physiological indices such as body composition and cardiorespiratory fitness will also be obtained. The ECU site (PI Joseph Houmard) will be responsible for testing 25% of the total (450 subjects) for the project. ECU will thus recruit and test 11-12 athletes, 11-12 dedicated control subjects (both of these groups will only require characterization and not exercise training), and 112-113 of the subjects examined before and after exercise training. These numbers will allow for a 20% drop-out rate from the exercise training groups with the goal of 89-91 subjects completing the training protocols at ECU. ECU will follow the protocols created by the MoTrPAC consortium which will created during the first year of planning.

Scholars @ ECU