Positions
- Assistant Professor, Anatomy and Cell Biology, Brody School of Medicine
- Contact Info
Co-author Network
Map of Science
Co-investigator Network
Alessandro Didonna
Affiliation
Publications
selected publications
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article
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Autoimmune demyelination alters hypothalamic transcriptome and endocrine function.
Journal of neuroinflammation.
21.
2024
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Ataxin-1 controls the expression of specific non-coding RNAs in B cells upon autoimmune demyelination.
Immunology and cell biology.
2023
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Cysteine carboxyethylation: a novel post-translational modification associated with autoimmune arthritis.
Signal transduction and targeted therapy.
8.
2023
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High-resolution DNA methylation screening of the major histocompatibility complex in multiple sclerosis.
Frontiers in Neurology.
14.
2023
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Integration of epigenetic and genetic profiles identifies multiple sclerosis disease-critical cell types and genes.
Communications biology.
6.
2023
- Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis. Journal of visualized experiments : JoVE. 2023
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A short HLA-DRA isoform binds the HLA-DR2 heterodimer on the outer domain of the peptide-binding site.
Archives of Biochemistry and Biophysics.
719.
2022
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Epigenetic control of ataxin-1 in multiple sclerosis.
Annals of clinical and translational neurology.
9:1186-1194.
2022
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Methylation at a conserved lysine residue modulates tau assembly and cellular functions.
Molecular and cellular neurosciences.
120.
2022
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Polygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans.
Brain : a journal of neurology.
2022
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A splice acceptor variant in HLA-DRA affects the conformation and cellular localization of the class II DR alpha-chain.
Immunology.
162:194-207.
2021
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Pharmacological perturbation reveals deficits in D2 receptor responses in Thap1 null mice.
Annals of clinical and translational neurology.
8:2302-2308.
2021
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Specific hypomethylation programs underpin B cell activation in early multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America.
118.
2021
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The novel multiple sclerosis susceptibility gene ATXN1 regulates B cell receptor signaling in B-1a cells.
Molecular brain.
14.
2021
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Ataxin-1 regulates B cell function and the severity of autoimmune experimental encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America.
117:23742-23750.
2020
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Oligodendrocyte-specific Argonaute profiling identifies microRNAs associated with experimental autoimmune encephalomyelitis.
Journal of neuroinflammation.
17.
2020
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Tau at the interface between neurodegeneration and neuroinflammation.
Genes and immunity.
21:288-300.
2020
- TopoDB: a novel multifunctional management system for laboratory animal colonies. Database : the journal of biological databases and curation. 2020. 2020
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Loss of the dystonia gene Thap1 leads to transcriptional deficits that converge on common pathogenic pathways in dystonic syndromes.
Human molecular genetics.
28:1343-1356.
2019
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Sex-specific Tau methylation patterns and synaptic transcriptional alterations are associated with neural vulnerability during chronic neuroinflammation.
Journal of autoimmunity.
101:56-69.
2019
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The role of neurofilament aggregation in neurodegeneration: lessons from rare inherited neurological disorders.
Molecular neurodegeneration.
14.
2019
- Aberrant STAT phosphorylation signaling in peripheral blood mononuclear cells from multiple sclerosis patients. Journal of neuroinflammation. 15. 2018
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Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1.
The Journal of clinical investigation.
128:2252-2265.
2018
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Hyperpolarized C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model.
Proceedings of the National Academy of Sciences of the United States of America.
114.
2017
- Post-translational modifications in neurodegeneration. AIMS Biophysics. 3:27-49. 2016
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Advances in Sequencing Technologies for Understanding Hereditary Ataxias: A Review.
JAMA Neurology.
73:1485-1490.
2016
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Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis.
Scientific Reports.
6.
2016
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Preclinical Models of Multiple Sclerosis: Advantages and Limitations Towards Better Therapies.
Current medicinal chemistry.
23:1442-59.
2016
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A non-synonymous single-nucleotide polymorphism associated with multiple sclerosis risk affects the EVI5 interactome.
Human molecular genetics.
24:7151-8.
2015
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Characterization of four new monoclonal antibodies against the distal N-terminal region of PrP(c).
PeerJ.
3.
2015
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Genetic determinants of risk and progression in multiple sclerosis.
Clinica chimica acta; international journal of clinical chemistry.
449:16-22.
2015
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The promise and perils of HDAC inhibitors in neurodegeneration.
Annals of clinical and translational neurology.
2:79-101.
2015
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The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1.
Human molecular genetics.
23:3733-45.
2014
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Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation.
The Journal of clinical investigation.
123:1964-75.
2013
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Prion protein and its role in signal transduction.
Cellular & molecular biology letters.
18:209-30.
2013
- The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells. Prion. 6:309-16. 2012
- Infrared microspectroscopy: a multiple-screening platform for investigating single-cell biochemical perturbations upon prion infection. ACS chemical neuroscience. 2:160-74. 2011
- Aberrant ERK 1/2 complex activation and localization in scrapie-infected GT1-1 cells. Molecular neurodegeneration. 5. 2010
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Autoimmune demyelination alters hypothalamic transcriptome and endocrine function.
Journal of neuroinflammation.
21.
2024
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chapter
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<span>Genetic Factors in Neuroimmune Diseases</span>.
Springer.
2024
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<span>Genetic Factors in Neuroimmune Diseases</span>.
Springer Cham.
2019
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The Genetics of Multiple Sclerosis.
Exon Publications.
2017
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<span>Genetic Factors in Neuroimmune Diseases</span>.
Springer.
2024
presentations
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presentation
- Analisis of Neuroinflammation in Animal Models of Neurological Diseases, Celebration of Microscopy at ECU 2025
- Creation of the First B-Cell Specific Ataxin-1 Conditional Knockout Mouse Model, Research and Creative Achievement Week (RCAW) 2025
- Multiomics profiling highlights a complex regulatory role for ataxin-1 in the B cell compartment upon autoimmune demyelination, ASCB-EMBO meeting Cell Bio 2024 2024
- The novel role of tau protein in autoimmune neuroinflammation, ECU Department of Chemistry seminar series 2024
- Integrated epigenetic and transcriptome analysis in multiple sclerosis, Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) Young Scientist Summit in Clinical Neuroimmunology 2024
- Autoimmune demyelination alters hypothalamic transcriptome and endocrine function, 25th Annual Symposium of the Eastern Carolina Chapter of the Society for Neuroscience 2024
- HLA-DRB1*04:01 has a Neuroprotective Role in a Mouse Model of Parkinson's Disease, 27th Annual Medical Student Scholarship Forum 2024
- Ataxin-1 controls distinct coding and non-coding RNA networks associated with the B cell response upon autoimmune demyelination, Joint ASCB-EMBO meeting Cell Bio 2023 2023
- Ataxin-1 beyond SCA1: a novel immunomodulatory role in multiple sclerosis, Duke-UNC Alzheimer's Disease Research Center (ADRC) IDEAS Forum 2023
- Tau misfolding and progression in multiple sclerosis, International Progressive MS Alliance Scientific Congress 2023
- Altered hypothalamic transcriptome in a mouse model of multiple sclerosis, Annual Symposium of the American Society for Neurochemistry 2023
- Identifying multiple sclerosis disease-critical cell types and genes by integration of epigenetic and genetic profiles, Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) Forum 2023
- Altered hypothalamic transcriptome in a mouse model of multiple sclerosis, 24th Annual Symposium of the Eastern Carolina Chapter of the Society for Neuroscience 2022
- Ataxin-1 is epigenetically regulated in B cells upon multiple sclerosis and exerts an immunomodulatory function against autoimmune demyelination, Joint ASCB-EMBO meeting Cell Bio 2022 2022
- Integrated epigenetic and transcriptome analysis in multiple sclerosis, Joint ASCB-EMBO meeting Cell Bio 2022 2022
- The novel immunomodulatory role of ataxin-1 in autoimmune demyelination, 24th Annual Symposium of the Eastern Carolina Chapter of the Society for Neuroscience 2022
Research
principal investigator on
- Development of a conditional ataxin-1 knockout mouse line awarded by DHHS - NIH/National Institute of Neurological Disorders and Stroke (NINDS) 2023 - 2026
- Multiple Sclerosis as a Noncanonical Tauopathy awarded by DOD - Department of Defense 2022 - 2025
- Exploring the interplay between phthalate exposure and autoimmune demyelination awarded by North Carolina State University (NCSU) 2024 - 2025
- Y2 Continuation: Exploring the role of centaurin alpha-1 in multiple sclerosis awarded by Wooten Family Initiative for Brain Health Research 2023 - 2024
- Exploring the role of centaurin alpha-1 in multiple sclerosis awarded by Wooten Family Initiative for Brain Health Research 2022 - 2024
- Tau misfolding and progression in multiple sclerosis awarded by NMSS - National Multiple Sclerosis Society 2021 - 2023
- The role of Ataxin1 in autoimmune demyelination awarded by University of California San Francisco (USCF) 2022 - 2023
- HLA genetics and Parkinson's disease awarded by DHHS - National Institutes of Health (NIH) 2022 - 2023
- Identification of targetable epitopes in neurotoxic tau oligomers using a physics-based approach awarded by The Stanford Program for Integrated Neuroscience Technologies (SPrINT) 2022 - 2023
investigator on
Service
professional service activities
- National Institutes of Health (NIH) Special Emphasis Panel Grant reviewer for the "Alzheimer's disease and its related dementias" (ZRG1 AN Z55) recurring panel 2022 - 2023
- ASCB-EMBO meeting Cell Bio 2023 Co-Chair of the Minisymposium "Molecular Basis of Nervous System Development" 2023
- DoD Multiple Sclerosis Research Program (MSRP) Grant reviewer for the US Department of Defense (DOD) Multiple Sclerosis Research Program (MSRP) "Activity & Progression - 1" (AP-1) panel 2023
- Evaluation of faculty for other universities University of California San Francisco (Dr. Jorge Oksenberg's promotion) 2023
- Dementia Alliance of North Carolina (DANC) Grant reviewer for the Dementia Alliance of North Carolina (DANC) 2022
- Wooten Brain Health Program Grant Reviewer for the Wooten Brain Health Program at Brody 2022
- American Society for Cell Biology (ASCB) 2022 Annual Meeting Judge for the ASCB 2022 Annual Meeting's Minorities Affairs Committee (MAC) and Education Committee (EdComm) Poster Session 2022
Background
education and training
- B.S. in Cellular and Molecular Biology, University of Bari
- M.S. in Cellular and Molecular Biology, University of Bari
- Ph.D. in Functional and Structural Genomics, International School for Advanced Studies (SISSA)