Exploring the role of centaurin alpha-1 in multiple sclerosis
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abstract
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Centaurin-?1 (CentA1) is a conserved protein that regulates the neuronal cytoskeleton. We hypothesize that CentA1 plays a role in the context of multiple sclerosis (MS), as part of an adaptive mechanism aimed at preserving neuronal integrity against inflammatory challenges. By combining histopathological and biochemical analyses with state of art genomic tools, we aim at elucidating the molecular determinants and regulation of CentA1 in MS and its mouse model, called experimental autoimmune encephalomyelitis (EAE). By characterizing the role of CentA1 in chronic central nervous system (CNS) inflammation, we expect to gain insight into the neurodegenerative processes underlying disease progression and the irreversible accumulation of disability.
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