Collaborative Research: The Role of Tension in the Digestion of Blood Clots. Grant uri icon

abstract

  • The primary structural elements in blood clots are fibrin fibers. Fibrin fibers polymerize at the end of the coagulation process and help to stabilize the clot structure. Upon the completion of wound healing, the fibers are digested by an enzyme called plasmin during fibrinolysis. The polymerization process creates tension in the fibers, and additional tension is exerted on the fibers by cells and fluid flow. The aim of this proposal is to determine the mechanisms by which tension regulates the fibrinolytic process.

date/time interval

  • February 2024 - April 2027