Positions
Publications in VIVO
Elizabeth Ables
Overview
overview
Elizabeth Ables received her B.S. degree from St. Andrews College in Laurinburg, NC, and M.S. degree from the University of North Carolina at Wilmington, where she developed a passion for developmental biology and undergraduate teaching. In 2007, she received her Ph.D. in Molecular Physiology and Developmental Biology from Vanderbilt University. Elizabeth received extensive training in the cis-regulatory control of gene expression and its impact on mammalian physiology, providing the foundation for her long-term research goal of elucidating the gene regulatory networks that control cellular specialization. To complement her existing strengths in microscopy and gene expression analyses, and to develop her work in a model system more amenable to undergraduate research, Elizabeth pursued post-doctoral work in the lab of Dr. Daniela Drummond-Barbosa at Johns Hopkins University. Combining her knowledge of physiology and development, and her interest in stem cells, Elizabeth's studies culminated in the discovery that the steroid hormone ecdysone, well-known for its role in the control of developmental timing in insects, directly modulated Drosophila germline stem cell activity. She began a faculty position at East Carolina University (ECU) in 2013 and is now Associate Professor in the Department of Biology. She leads a diverse team of undergraduate and graduate researchers who study the molecular mechanisms by which germline stem cells balance proliferation and differentiation. Over the last ten years, the Ables Lab has received more than $1.5 million in support of their research, including funds from the March of Dimes (Basil O'Connor Research Scholar Award) and the National Institutes of Health (Academic Research Enhancement Awards). Elizabeth also continues to use her research in stem cell biology as a teaching tool and her lab as an active mentoring environment for undergraduate education. She currently serves as Program Lead for the MARC@ECU Biomedical Scholars Program, a $1.2 million grant program from the National Institutes of Health that supports the training and mentorship of undergraduate researchers from underserved communities. In recognition of her leadership, scholarship, and effective teaching in and outside of the classroom, Elizabeth is the recipient of numerous awards, including the UNC Board of Governors Excellence in Teaching Award (2023), the ECU Five-Year Achievement in Research &; Creative Activity Award (2022), the ECU Honors College Faculty Mentor Award (2021), the Provost's Scholar-Teacher Award (2020), the Dean's Early Career Award (2018), the Board of Governors Distinguished Professor for Teaching Award (2018), and the ECU Distinguished Faculty Mentor Award (2017). In her free time, Elizabeth enjoys spending time outdoors, particularly bicycling, kayaking, and hiking with her family.
Publications
presentations
presentation
Characterizing the Effects of the Overexpression of Eip75B in Drosophila . ,
66th Annual Drosophila Research Conference 2025
Ecdysone signaling and BMP signaling converge to regulate ovarian germline stem cell maintenance and differentiation. ,
66th Annual Drosophila Research Conference 2025
Ovarian germ cells use EcR to stimulate timely cyst packaging. ,
66th Annual Drosophila Research Conference 2025
Over-expression of the Ecdysone Receptor promotes an undifferentiated transitional state during germline stem cell differentiation. ,
Triangle Fly Symposium 2024
Investigating the nuclear requirement for Tnpo-SR in Drosophila germline stem cell self-renewal. ,
The Allied Genetics Conference 2024
Investigating the role of Ecdysone Receptor in germline cyst growth and progression. ,
Triangle Fly Symposium 2024
Investigating the role of Ecdysone Receptor in germline to somatic cell communication. ,
The Allied Genetics Conference 2024
Investigating the role of SRPK in Drosophila germline stem cells. ,
The Allied Genetics Conference 2024
Over-expression of EcR-B in germ cells promotes a germline stem cell-like fate during germline differentiation. ,
The Allied Genetics Conference 2024
Tnpo-SR promotes microtubule dynamics and fusome morphogenesis in germline stem cells. ,
The Allied Genetics Conference 2024
Investigating ecdysone signaling in Drosophila germ cells. ,
Triangle Consortium for Reproductive Biology 2023
Investigating germline stem cell establishment and polarity in Drosophila melanogaster . ,
Triangle Consortium for Reproductive Biology 2023
Novel roles for Ecdysone Receptor in the Drosophila germline. ,
Southeast Regional Meeting of the Society for Developmental Biology 2022
Exploring the role of Oatp74D, an Ecdysone Importer, in the Drosophila Ovary ,
63rd Annual Drosophila Research Conference 2022
Tnpo-SR is required for fusome morphogenesis in Drosophila ovarian germline stem cells ,
63rd Annual Drosophila Research Conference 2022
Exploring the role of Oatp74D, an Ecdysone Importer, in the Drosophila Ovary ,
State of NC Undergraduate Research and Creativity Symposium 2021
Tnpo-SR is required for GSC fusome dynamics in Drosophila. ,
State of NC Undergraduate Research and Creativity Symposium 2021
Beta importins promote ovarian cyst formation in Drosophila ,
Southeast Regional Meeting of the Society for Developmental Biology 2021
Ran and associated karyopherins Cadmus and Tnpo-SR maintain ovarian cyst connectivity. ,
62nd Annual Drosophila Research Conference 2021
Ran regulates germ cell mitotic divisions in Drosophila. ,
State of NC Undergraduate Research and Creativity Symposium 2020
Balancing cell proliferation and cell fate in the Drosophila germline. ,
Duke/UNC Fly Club 2020
Exploring the mechanisms of ecdysone signaling in Drosophila melanogaster oocyte development. ,
The Allied Genetics Conference 2020
Germ cell division and encapsulation by somatic cells during Drosophila oogenesis require the orphan nuclear receptor ftz-f1. ,
The Allied Genetics Conference 2020
The karyopherin Tnpo-SR promotes fusome integrity in Drosophila germline cysts. ,
The Allied Genetics Conference 2020
Exploring the role of ecdysone signaling in Drosophila oocyte development. ,
Emerging Researchers National (ERN) Conference in STEM 2020
Supplementing your research funds while improving diversity: focus on undergraduate research and training. ,
East Carolina University, Division of Research, Economic Development and Engagement and Office of Equity and Diversity 2020
Exploring the role of ecdysone signaling in Drosophila oocyte development. ,
Annual Biomedical Research Conference for Minority Students 2019
Towards understanding the balance of cell fate and cell proliferation using Drosophila. ,
University of South Carolina Department of Biology Seminar Series 2019
A steroid hormone promotes germ cell mitotic divisions and oocyte specification in Drosophila. ,
Southeast Regional Meeting of the Society for Developmental Biology 2019
Orphan nuclear hormone receptor ftz-f1 is necessary to promote essential developmental checkpoints during oogenesis. ,
Southeast Regional Meeting of the Society for Developmental Biology 2019
Stem cells on steroids: connecting physiological signals with stem cell proliferation and differentiation. ,
Southeast Regional Meeting of the Society for Developmental Biology 2019
Molecular chaperoneTetratricopeptide repeat protein 2(Tpr2) is essential for germline stem cell self-renewal and timely cyst divisions inDrosophilaoogenesis. ,
60th Annual Drosophila Research Conference 2019
Nuclear hormone receptor ftz-f1 is necessary in both the germline and soma to promote oocyte development. ,
60th Annual Drosophila Research Conference 2019
Identification of ecdysone signaling targets in early Drosophila melanogaster oogenesis ,
28th Annual Meeting of the Triangle Consortium for Reproductive Biology 2019
Nuclear hormone receptor ftz-f1 is necessary to promote oogenesis. ,
28th Annual Meeting of the Triangle Consortium for Reproductive Biology 2019
Building a stair-stepped student mentoring model. ,
College of Health and Human Performance Lunch and Learn 2018
A conserved nuclear transport protein promotes germ cell division and oocyte specification in Drosophila. ,
Cold Spring Harbor Germ Cells Meeting 2018
Identification of interacting partners of Tnpo-SR in the control of germline cell divisions in the Drosophila ovary ,
77th Annual Meeting of the Society for Developmental Biology 2018
Investigating combinatorial transcriptional control of ecdysone response gene E74 during cyst development in the Drosophila ovary. ,
Mid-Atlantic Regional Meeting of the Society for Developmental Biology 2018
Steroid hormone regulation of distinct RNA-binding proteins promotes GSC self-renewal. ,
Annual Triangle Fly Symposium 2018
ftz-f1 is necessary to maintain germline stem cell function in Drosophila oogenesis ,
Mid-Atlantic Regional Meeting of the Society for Developmental Biology 2018
The nuclear transport protein Tnpo-SR promotes cell proliferation and oocyte specification in the early Drosophila germline. ,
59th Annual Drosophila Research Conference 2018
Select hnRNPs facilitate the establishment and maintenance of germline stem cells in Drosophila melanogaster. ,
Triangle Consortium for Reproductive Biology 2018
Steroid hormone signaling promotes Drosophila ovarian germline stem cell self-renewal via recruitment of multifunctional RNA binding proteins. ,
Triangle Consortium for Reproductive Biology 2018
Nuclear transport protein, Transportin Serine-Arginine rich, is required for germline stem cell proliferation and self-renewal in Drosophila. ,
American Society for Cell Biology Annual Meeting 2017
CRL5 is required in somatic cells for cyst encapsulation during early follicle development. ,
Southeast Regional Meeting of the Society for Developmental Biology 2017
Distinct Hnrnps regulate germline stem cell self-renewal in response to ecdysone signaling. ,
Triangle Fly Symposium 2017
Exploring the Regulation of ftz-f1 Expression in the Drosophila Ovary. ,
Southeast Regional Meeting of the Society for Developmental Biology 2017
Investigating the molecular control of the ecdysone response gene, E74, in Drosophila ovarian germ cells. ,
Southeast Regional Meeting of the Society for Developmental Biology 2017
Nuclear hormone receptor ftz-f1 controls Drosophila germline stem cell establishment. ,
Triangle Fly Symposium 2017
Ecdysone signaling controls germline stem cell maintenance by promoting expression of distinct RNA binding proteins. ,
Ecdysone Workshop, 58th Annual Drosophila Research Conference 2017
Drosophila ovarian stem cell establishment is regulated by nuclear hormone receptor ftz-f1. ,
Triangle Consortium for Reproductive Biology 2017
The Fly-FUCCI system demonstrates fundamental changes in cell cycle regulation accompany differentiation in the early Drosophila germline. ,
Triangle Consortium for Reproductive Biology 2017
E2f1 is dispensable for germline stem cell maintenance and proliferation. ,
The Allied Genetics Conference 2016
Hrb27C functionally interacts with ecdysone signaling to maintain the Drosophila female germline stem cell fate. ,
The Allied Genetics Conference 2016
Drosophila Mcm10 is required for female reproductive success ,
56th Annual Drosophila Research Conference 2015
Investigating the role of Hrb27C in the regulation of female germline stem cell activity ,
56th Annual Drosophila Research Conference 2015
Research
principal investigator on
co-principal investigator on
investigator on
Service
professional service activities
Biology Open
2023 - 2024
Cell Press
2023 - 2024
Developmental Biology
2023 - 2024
Frontiers in Cell and Developmental Biology
2023 - 2024
Genesis
2023 - 2024
Insect Molecular Biology
2023 - 2024
Journal of Cell Biology
2023 - 2024
Journal of Visualized Experiments
2023 - 2024
Ad hoc reviewer, NIH Center for Scientific Review, Cell Signaling and Molecular Endocrinology Study Section
2024
Ad hoc reviewer, NIH Center for Scientific Review, R15 Special Emphasis Panel
2023
Communications Biology
2023
Journal of Cell Science
2023
Proceedings of the National Academy of Science
2023
Genetics
2020 - 2023
Nature
2020 - 2023
PLoS ONE
2020 - 2023
Scientific Reports
2018 - 2023
PLoS Genetics
2018 - 2023
Development
2017 - 2023
PLoS Biology
2017 - 2023
G3: Genes Genomes Genetics
2016 - 2023
Fly
2015 - 2023
Molecular Reproduction and Development
2015 - 2023
Ad hoc reviewer, NIH Center for Scientific Review, S10 Instrumentation Award Panel
2023
Ad hoc reviewer, Natural Sciences and Engineering Research Council of Canada
2023
Ad hoc "subject matter expert" reviewer, NIH Center for Scientific Review, Director's Early Independence Award Panel
2022
Ad hoc reviewer, NSF Division of Integrated Organismal Systems, Developmental Systems Cluster
2021
Ad hoc reviewer, NIH Center for Scientific Review, Cellular, Molecular, and Integrative Reproduction (CMIR) Study Section
2021
Reviewer, Princeton University Press
2021
Southeast Regional Meeting of the Society for Developmental Biology
Co-organizer 2020
Invited Guest Editor, Developmental Biology, Special Issue on "Nutritional, Hormonal, and Metabolic Drivers of Development"
2020
Ecdysone Workshop at the Annual Drosophila Research Conference
Co-organizer 2017
Triangle Fly Symposium
Session chair and invited speaker. 2015
RTI International, NIH Eastern Regional Comprehensive Metabolomics Resource Core
2014