Lipid Metabolism in Obesity, Weight-Loss and Exercise
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Overview
abstract
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40 kg/m2) individuals display a decrement in fatty acid oxidation in skeletal muscle which may lead to positive lipid balance and ectopic lipid accumulation. The broad, long-term objective of the current proposal is to discern the cellular mechanisms responsible for the reduction in fatty acid oxidation in the skeletal muscle of severely obese humans and if exercise training functions as an effective intervention. The relevance of this work is that the incidence of severe obesity is increasing disproportionately and associated with elevated health costs; findings obtained could aid in understanding the underlying biology of this condition and designing treatments as well as promoting physical activity as an effective intervention/prevention for severe obesity.
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