Protocolized Care for Early Septic Shock
Grant
Overview
abstract
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The study objective is to improve the management of septic shock by exploring the clinical, biological, and economic aspects of alternative resuscitation strategies. This will be done by comparing two alternative resuscitation strategies, Early Goal Directed Therapy (EGDT) or Protocolized Standard Care (PSC), to usual care in subjects with septic shock. Aim #1: To compare the clinical efficacy of alternative resuscitation strategies for septic shock Aim #2: To better understand the mechanisms by which resuscitation strategies affect clinical outcomes. Aim #3: To assess the costs and cost-effectiveness of the alternative resuscitation strategies. This proposal will provide new, important and comprehensive data on the clinical, biologic, and pragmatic aspects of a key therapy for a common and serious medical condition. Sepsis and septic shock affects over 750,000 people yearly in the U.S. and is the cause of death for 215,000. The findings will aid scientists, clinicians, families and policymakers and will immediately affect care of the critically ill. As the number of Americans dying with sepsis is similar to that of acute myocardial infarction, the proposed study has enormous implications for the public health of the country and is consistent with the recent NIH emphasis on translational research.
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