Tissue Specific Impact of Organic Cations on Mitochondrial Energy Transduction
Grant
Overview
abstract
-
Many commonly prescribed drugs induce significant side effects and/or toxicity in metabolically active tissues. Emerging evidence suggests that mitochondria, a critical subcellular organelle that are enriched in metabolically active tissues, may be particularly sensitive to drug interactions resulting in a range of complex physiological effects. The proposed studies will determine specific details of drug interactions with mitochondria isolated from different tissues and identify potential mediators of the effects that can be targeted to improve drug design and reduce tissue specific side effects/toxicities.
date/time interval
-
September 2021 - March 2023
awarded by