EEG in Children with Hemiplegia for Biomarker Development: The EMBARK Study Grant uri icon

abstract

  • Corticomuscular coherence (CMC) is a measurement that reflects synchrony between the central and peripheral nervous systems through simultaneous collection and analysis of electroencephalography (EEG) and electromyography (EMG) signals, respectively. Past work has shown that adults with stroke typically demonstrate reduced CMC compared to age-matched controls and that the degree of symmetry in CMC between affected and less affected sides, representative of ipsi- and contralesional corticospinal tract systems, corresponds to more favorable motor status and post-stroke motor recovery. This pilot study will assess the feasibility of CMC measurements from both affected and less affected upper extremities in children and adolescents with hemiplegia (Year 1) and examine its utility as a biomarker of upper extremity treatment response (Year 2).
  • Corticomuscular coherence (CMC) is a measurement that reflects synchrony between the central and peripheral nervous systems through simultaneous collection and analysis of electroencephalography (EEG) and electromyography (EMG) signals, respectively. Past work has shown that adults with stroke typically demonstrate reduced CMC compared to age-matched controls and that the degree of symmetry in CMC between affected and less affected sides, representative of ipsi- and contralesional corticospinal tract systems, corresponds to more favorable motor status and post-stroke motor recovery. This pilot study will assess the feasibility of CMC measurements from both affected and less affected upper extremities in children and adolescents with hemiplegia (Year 1).

date/time interval

  • October 2021 - December 2022