Atlantic Mackerel Vitamin A Inflammation and Microbiome Grant uri icon

abstract

  • Dietary intervention of vitamin A-enriched foods could potentially contribute to an anti-inflammatory gut microbiome profile and reduce colonic and systemic inflammation in humans, through unclear mechanisms. Atlantic mackerel fish is a commonly available seafood containing high vitamin A, predominantly retinol, in the fish fillets. There remains a substantial knowledge gap regarding the role of the gut microbiome in mediating the purported health benefits of dietary Atlantic mackerel. Thus, we propose an pre-clinical approach using young-adult Sprague Dawley rats as models to pursue the following two specific objectives: 1) Evaluate the anti-inflammatory properties of Atlantic mackerel fish fillets via rebalancing of gut microbiome in DSS-induced intestinal inflammation (inflammatory bowel disease, IBD), and test the role of diet-induced gut microbiome alteration on inflammation in germ-free mice. 2) Determine the underlying metabolic mechanism by which retinol, as one of the Atlantic mackerel bioactive compounds, exerts the anti-inflammatory role through regulating certain aspects of gut microbiome growth, metabolism, and function in vitamin A deficient DSS rat models.

date/time interval

  • February 2022 - December 2024