overview

• My research interests lie in proteomics, bioinformatics, epigenetics and epitranscriptomics, and DNA damage. During my graduate studies in Dr. Yuqi Feng's lab at Wuhan University (China), I developed a variety of new adsorbent materials for the enrichment of phosphopeptides/glycopeptides and environmental toxicants, as well as their subsequent mass spectrometric analysis. Building on my expertise in using mass spectrometry (MS)-based method to study protein post-translational modifications, I extended my research interest to MS-based proteomic studies in my postdoctoral research in Dr. Yinsheng Wang's lab at UC-Riverside. During my postdoctoral study, my research mainly focuses on developing quantitative proteomics and bioinformatics methods to identify novel binding proteins of nucleic acids, including damaged DNA, G-quadruplex, R-loop and modified RNA, and exploring the functions and molecular mechanisms of these novel interactions in cells.
  My future research will focus on developing quantitative proteomics and bioinformatics methods to identify novel protein-protein interactions and novel binding proteins of nucleic acids, including damaged DNA, G-quadruplexes, R-loops, and modified RNA. I aim to elucidate the biochemical mechanisms and functional roles of these interactions in cells. My current research will primarily focus on two key areas:
  
  Deciphering the novel crosstalk between m6A modification and histone post-translational modifications within chromatin, and elucidating the biological functions of these interactions in human cells. The outcomes of this research will significantly enhance our understanding of the molecular mechanisms driving m6A-mediated epigenetic regulation in both physiological and pathological contexts, laying the groundwork for the development of effective cancer treatment strategies.
  Identifying novel R-loop-binding proteins and investigating the impact of disease-relevant mutations in proteins or environmental exposure on these interactions in human cells. The outcome of this research will provide a biochemical basis for a better understanding of the functional roles of protein-R-loop interactions in cells, as well as offer insights into how protein mutations or environmental exposure contribute to genome instability.