overview

• The overarching goal of my research is to understand the bidirectional communication between the central nervous system and the immune system in regulation of cardiovascular and neurodegenerative diseases. The major focus of the lab is on investigating the role of kinin B1 receptor mediated inflammatory pathways and signaling mechanisms in the development of neurogenic hypertension. My laboratory uses an integrated physiological, pharmacological, molecular and gene-targeting approach, employingin vivoanimal models of human diseases, complemented byin vitroprimary cell cultures and cell lines. Some of the techniques used in our lab include blood pressure and heart rate recordings in conscious free moving mice using telemetry system, autonomic function assessment, brain nuclei-targeted microinjections, electron/fluorescence microscopy, and routine cell and molecular biology techniques. The major goal of my laboratory research is to elucidate mechanisms underlying the pathophysiology and identify novel potential therapeutic targets for the treatment of cardiovascular and neurodegenerative diseases.