Alessandro Didonna

Publications

selected publications

article
- Loss of ADAP1/CentA1 protects against autoimmune demyelination
  . The FASEB Journal. 2025
- Autoimmune demyelination alters hypothalamic transcriptome and endocrine function. Journal of neuroinflammation. 21. 2024
- Lipid metabolism is dysregulated in endocrine glands upon autoimmune demyelination. Journal of neuroimmunology. 391. 2024
- Ataxin-1 controls the expression of specific non-coding RNAs in B cells upon autoimmune demyelination. Immunology and cell biology. 2023
- Cysteine carboxyethylation: a novel post-translational modification associated with autoimmune arthritis. Signal transduction and targeted therapy. 8. 2023
- High-resolution DNA methylation screening of the major histocompatibility complex in multiple sclerosis. Frontiers in Neurology. 14. 2023
- Integration of epigenetic and genetic profiles identifies multiple sclerosis disease-critical cell types and genes. Communications biology. 6. 2023
- Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis. Journal of visualized experiments : JoVE. 2023
- A short HLA-DRA isoform binds the HLA-DR2 heterodimer on the outer domain of the peptide-binding site. Archives of Biochemistry and Biophysics. 719. 2022
- Epigenetic control of ataxin-1 in multiple sclerosis. Annals of clinical and translational neurology. 9:1186-1194. 2022
- Methylation at a conserved lysine residue modulates tau assembly and cellular functions. Molecular and cellular neurosciences. 120. 2022
- Polygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans. Brain : a journal of neurology. 2022
- A splice acceptor variant in HLA-DRA affects the conformation and cellular localization of the class II DR alpha-chain. Immunology. 162:194-207. 2021
- Pharmacological perturbation reveals deficits in D2 receptor responses in Thap1 null mice. Annals of clinical and translational neurology. 8:2302-2308. 2021
- Specific hypomethylation programs underpin B cell activation in early multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America. 118. 2021
- The novel multiple sclerosis susceptibility gene ATXN1 regulates B cell receptor signaling in B-1a cells. Molecular brain. 14. 2021
- Ataxin-1 regulates B cell function and the severity of autoimmune experimental encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America. 117:23742-23750. 2020
- Oligodendrocyte-specific Argonaute profiling identifies microRNAs associated with experimental autoimmune encephalomyelitis. Journal of neuroinflammation. 17. 2020
- Tau at the interface between neurodegeneration and neuroinflammation. Genes and immunity. 21:288-300. 2020
- TopoDB: a novel multifunctional management system for laboratory animal colonies. Database : the journal of biological databases and curation. 2020. 2020
- Loss of the dystonia gene Thap1 leads to transcriptional deficits that converge on common pathogenic pathways in dystonic syndromes. Human molecular genetics. 28:1343-1356. 2019
- Sex-specific Tau methylation patterns and synaptic transcriptional alterations are associated with neural vulnerability during chronic neuroinflammation. Journal of autoimmunity. 101:56-69. 2019
- The role of neurofilament aggregation in neurodegeneration: lessons from rare inherited neurological disorders. Molecular neurodegeneration. 14. 2019
- Aberrant STAT phosphorylation signaling in peripheral blood mononuclear cells from multiple sclerosis patients. Journal of neuroinflammation. 15. 2018
- Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1. The Journal of clinical investigation. 128:2252-2265. 2018
- Hyperpolarized C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model. Proceedings of the National Academy of Sciences of the United States of America. 114. 2017
- Post-translational modifications in neurodegeneration. AIMS Biophysics. 3:27-49. 2016
- Advances in Sequencing Technologies for Understanding Hereditary Ataxias: A Review. JAMA Neurology. 73:1485-1490. 2016
- Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis. Scientific Reports. 6. 2016
- Preclinical Models of Multiple Sclerosis: Advantages and Limitations Towards Better Therapies. Current medicinal chemistry. 23:1442-59. 2016
- A non-synonymous single-nucleotide polymorphism associated with multiple sclerosis risk affects the EVI5 interactome. Human molecular genetics. 24:7151-8. 2015
- Characterization of four new monoclonal antibodies against the distal N-terminal region of PrP(c). PeerJ. 3. 2015
- Genetic determinants of risk and progression in multiple sclerosis. Clinica chimica acta; international journal of clinical chemistry. 449:16-22. 2015
- The promise and perils of HDAC inhibitors in neurodegeneration. Annals of clinical and translational neurology. 2:79-101. 2015
- The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1. Human molecular genetics. 23:3733-45. 2014
- Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation. The Journal of clinical investigation. 123:1964-75. 2013
- Prion protein and its role in signal transduction. Cellular & molecular biology letters. 18:209-30. 2013
- The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells. Prion. 6:309-16. 2012
- Infrared microspectroscopy: a multiple-screening platform for investigating single-cell biochemical perturbations upon prion infection. ACS chemical neuroscience. 2:160-74. 2011
- Aberrant ERK 1/2 complex activation and localization in scrapie-infected GT1-1 cells. Molecular neurodegeneration. 5. 2010
chapter
- <span>Genetic Factors in Neuroimmune Diseases</span>. Springer. 2024
- <span>Genetic Factors in Neuroimmune Diseases</span>. Springer Cham. 2019
- The Genetics of Multiple Sclerosis. Exon Publications. 2017

Service

professional service activities

National Institutes of Health (NIH) Special Emphasis Panel Grant reviewer for the "Alzheimer's disease and its related dementias" (ZRG1 AN Z55) recurring panel 2022 - 2023
ASCB-EMBO meeting Cell Bio 2023 Co-Chair of the Minisymposium "Molecular Basis of Nervous System Development" 2023
DoD Multiple Sclerosis Research Program (MSRP) Grant reviewer for the US Department of Defense (DOD) Multiple Sclerosis Research Program (MSRP) "Activity & Progression - 1" (AP-1) panel 2023
Evaluation of faculty for other universities University of California San Francisco (Dr. Jorge Oksenberg's promotion) 2023
Dementia Alliance of North Carolina (DANC) Grant reviewer for the Dementia Alliance of North Carolina (DANC) 2022
Wooten Brain Health Program Grant Reviewer for the Wooten Brain Health Program at Brody 2022
American Society for Cell Biology (ASCB) 2022 Annual Meeting Judge for the ASCB 2022 Annual Meeting's Minorities Affairs Committee (MAC) and Education Committee (EdComm) Poster Session 2022

Background

education and training

B.S. in Cellular and Molecular Biology, University of Bari
M.S. in Cellular and Molecular Biology, University of Bari
Ph.D. in Functional and Structural Genomics, International School for Advanced Studies (SISSA)

VIVO

Positions

Alessandro Didonna

Affiliation

member of

Publications

selected publications

article

chapter

presentations

presentation

Research

principal investigator on

investigator on

Service

professional service activities

Background

education and training

awards and honors

Contact

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